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Search Results for " antiproliferative activity "

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186

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
TQ0059	Ilorasertib	ABT-348	VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
	Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...		VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
T9974	Antiproliferative agent-13		Dehydrogenase
	Antiproliferative agent-13 is a compound with antiproliferative activity.		Dehydrogenase
T64391	Antiproliferative agent-15		Others
	Antiproliferative agent-15 is a reagent with anticancer activity. Antiproliferative agent-15 showed antiproliferative activity against human colon cancer (HCT116 and HCT15) and brain cancer (LN-229 and GBM-10).		Others
T70086	EPZ033294		Others
	EPZ033294 has potential anticancer and antiproliferative activity.		Others
T64348	Antiproliferative agent-16	Antiproliferative agent-16	Others
	Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for...		Others
T60129	MT189	Antiproliferative agent-14	Microtubule Associated
	MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...		Microtubule Associated
T11337	Fumarate hydratase-IN-1		Others
	Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor.		Others
T9973	FAK-IN-7		FAK
	FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.		FAK
T35329L	EAD1 TFA(1644388-26-0 Free base)	EAD1 HCL(1644388-26-0 Free base)	Apoptosis , Autophagy
	EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis		Apoptosis , Autophagy
T77558	5,7-Dimethoxy-4-methylcoumarin		Antioxidant
	5,7-Dimethoxy-4-methylcoumarin has potential antioxidant antiproliferative and anticancer or activity.		Antioxidant
T64372	DB722		Others
	DB722 is a furamidine analogues with DNA binding activity. DB722 shows antiproliferative activity.		Others
T77732L	HFY-4A HCL (2094810-82-7 Free base)
	HFY-4A HCL is a novel HDAC inhibitor.HFY-4A HCL has antitumour activity and has shown antiproliferative activity in breast cancer cells.
T11823	LB-60-OF61		NAMPT
	LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.		NAMPT
T13148	CHK-IN-1		Chk
			Chk
T67735	Auristatin23		Others
	Auristatin23 is an Antitumor agent. Auristatin23 exhibits antiproliferative activity on tumor cell lines.		Others
T77716	Wnt pathway inhibitor 4		Antibacterial
	Wnt pathway inhibitor 4 is a small molecule antimicrobial agent with antibacterial and antiproliferative activity against cancer cells.		Antibacterial
T77667	PI3Kδ-IN-16		Apoptosis , PI3K
	PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.		Apoptosis , PI3K
T27582	ICRT-5	iCRT 5,iCRT5	Apoptosis , Wnt/beta-catenin
	iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be used in the study of multiple myeloma.		Apoptosis , Wnt/beta-catenin
T72062	BI-2865		Ras
	BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cel...		Ras
T14125	Adarotene	ST1926	Apoptosis
	Adarotene (ST1926) is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.		Apoptosis
T77731	ERK5-IN-6		ERK
	ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in the study of central nervous system-related disorders.		ERK
T35054	Vilaprisan	BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670	Progesterone Receptor
	Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids.		Progesterone Receptor
T21804	GW 610		Others
	GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0....		Others
T19812	Propentofylline	HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE
	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...		PDE
T61318	BRD4 Inhibitor-20		Epigenetic Reader Domain
	BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon canc...		Epigenetic Reader Domain
T77631	Enpp/Carbonic anhydrase-IN-2		Apoptosis , PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-I...		Apoptosis , PDE , Carbonic Anhydrase
T35901	EGFR-IN-99	JBJ-03-142-02	EGFR , HER
	EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC).		EGFR , HER
T73350	BAY-3827		Acyltransferase , AMPK
	BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer model. BAY-3827 inhibits the phosphorylation of acetyl CoA ...		Acyltransferase , AMPK
T64167L	Ifebemtinib FA	BI-853520 FA（1227948-82-4 Free base)	FAK
	Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.		FAK
T9150	SCR130	1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-	Apoptosis , Others , DNA/RNA Synthesis
	SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) is enzyme inhibition, antiproliferative effects and antifungal activity.		Apoptosis , Others , DNA/RNA Synthesis
T78701	Tubulin inhibitor 32		Apoptosis
	Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.		Apoptosis
T3521	γ-Secretase-IN-1	Compound E	Beta Amyloid , Gamma-secretase
	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.		Beta Amyloid , Gamma-secretase
T63429	SMO-IN-2		Hedgehog/Smoothened
	SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c...		Hedgehog/Smoothened
T15789	LTURM34		DNA-PK , PI3K , PI4K
	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .		DNA-PK , PI3K , PI4K
T72084	(R)-BI-2852		Ras
	(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agen...		Ras
T77502	Wnt pathway inhibitor 3		Wnt/beta-catenin , Adenylyl cyclase
	Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta...		Wnt/beta-catenin , Adenylyl cyclase
T77685	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile		PDK
	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study angiosarcoma, adenocarcinoma, multiple myeloma, psoriasis, prostate can...		PDK
T5152	MKT-077	MKT 077,FJ-776,MKT077	HSP
	MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular ...		HSP
T68896	Daniquidone	NSC 320846,BAY-H 2049	Topoisomerase
	Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DNA fragmentation for the study of neoplasms, immune disorder...		Topoisomerase
T71399	Plogosertib	CYC140	PLK
	Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of s...		PLK
T23897	CLK1/2-IN-3	CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3	CDK
	CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, wh...		CDK
T12660L	BAY1238097		Epigenetic Reader Domain
			Epigenetic Reader Domain
T77525	EN450		NF-κB
	EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be us...		NF-κB
T50056	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide		Others
	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordina...		Others
T11157L	EGFR-IN-1 hydrochloride		EGFR
	EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride exhibits potent antitumor and antiproliferative activity...		EGFR
T15181	DuP-697		COX
	DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic...		COX
T62281	PARP-1-IN-2		PARP
	PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...		PARP
T27392	FT001		Epigenetic Reader Domain
	FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects ag...		Epigenetic Reader Domain
T67775	Enpp/Carbonic anhydrase-IN-1		PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv...		PDE , Carbonic Anhydrase

Compounds

D-64131

T1753

Synonym:

Target: Microtubule Associated

Ilorasertib

TQ0059

Synonym: ABT-348

Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase

Antiproliferative agent-13

T9974

Synonym:

Target: Dehydrogenase

Antiproliferative agent-15

Antiproliferative agent-16

T64348

Synonym: Antiproliferative agent-16

Target: Others

MT189

T60129

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

Fumarate hydratase-IN-1

EAD1 TFA(1644388-26-0 Free base)

T35329L

Synonym: EAD1 HCL(1644388-26-0 Free base)

Target: Apoptosis, Autophagy

5,7-Dimethoxy-4-methylcoumarin

HFY-4A HCL (2094810-82-7 Free base)

Wnt pathway inhibitor 4

T77716

Synonym:

Target: Antibacterial

PI3Kδ-IN-16

T77667

Synonym:

Target: Apoptosis, PI3K

iCRT-5

T27582

Synonym: iCRT 5,iCRT5

Target: Apoptosis, Wnt/beta-catenin

Synonym: BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670

Target: Progesterone Receptor

Synonym: HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285

Target: Epigenetic Reader Domain

Enpp/Carbonic anhydrase-IN-2

T77631

Synonym:

Target: Apoptosis, PDE, Carbonic Anhydrase

EGFR-IN-99

T35901

Synonym: JBJ-03-142-02

Target: Acyltransferase, AMPK

Ifebemtinib FA

T64167L

Synonym: BI-853520 FA（1227948-82-4 Free base)

Target: FAK

SCR130

T9150

Synonym: 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

Target: Apoptosis, Others, DNA/RNA Synthesis

Target: Beta Amyloid, Gamma-secretase

SMO-IN-2

T63429

Synonym:

Target: Hedgehog/Smoothened

LTURM34

T15789

Synonym:

Target: DNA-PK, PI3K, PI4K

Wnt pathway inhibitor 3

T77502

Synonym:

Target: Wnt/beta-catenin, Adenylyl cyclase

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile

Synonym: MKT 077,FJ-776,MKT077

Target: HSP

Daniquidone

T68896

Synonym: NSC 320846,BAY-H 2049

Target: Topoisomerase

Synonym: CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3

Target: Epigenetic Reader Domain

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide

T50056

Synonym:

Target: Others

EGFR-IN-1 hydrochloride

Target: Epigenetic Reader Domain

Enpp/Carbonic anhydrase-IN-1

T67775

Synonym:

Target: PDE, Carbonic Anhydrase

カタログ番号	製品名	別名	ターゲット
TN4569	Minimolide F		Others
	Minimolide F, isolated from Centipeda minima, shows antiproliferative activity against human nasopharyngeal cancer cells with an IC50 of 17.4 μM.		Others
TC0039	Vasicinone		Others
	Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer...		Others
T9605	Sangivamycin	BA-90912,NSC 65346	Nucleoside Antimetabolite/Analog , PKC
	Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.		Nucleoside Antimetabolite/Analog , PKC
TN1933	Mitraphylline		IL Receptor , TNF , NF-κB
	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.		IL Receptor , TNF , NF-κB
TN1675	Gardenin B		Apoptosis , ROS , Caspase , NO Synthase
	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .		Apoptosis , ROS , Caspase , NO Synthase
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
T3916	Ginsenoside F2		Apoptosis , Endogenous Metabolite , Autophagy
	Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction.		Apoptosis , Endogenous Metabolite , Autophagy
T6102	2'-acetylacteoside		Antioxidant , Reductase
	2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo...		Antioxidant , Reductase
T3S1967	(S)-Indoximod	N-ME-Tryptophan,Abrine,L-Abrine	Others , Indoleamine 2,3-Dioxygenase (IDO)
	(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L...		Others , Indoleamine 2,3-Dioxygenase (IDO)
T75643	Isoxanthohumol		HSV
	Isoxanthohumol is a prenylated flavonoid derived from hops and beer with antiproliferative activity against several human cancer cell lines.Isoxanthohumol inhibits the metastasis or invasion of lung metastases of tumor c...		HSV
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T14305	Apicidin	OSI 2040	Apoptosis , HDAC , Autophagy
	Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ...		Apoptosis , HDAC , Autophagy
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
T81794	Micromonosporamide A
	Micromonosporamide A demonstrates antiproliferative activity contingent upon glutamine presence.
T17270	Yatein		Others
	Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.		Others
T81996	Kadsuphilin A
	Kadsuphilin A, extracted from Kadsura coccinea (Lem.), exhibits weak antiproliferative activity [1].
TN1810	Jatropholone B		Others
	Jatropholone B shows antiproliferative activity against cancer cell lines. It also has gastroprotective activity in preventing the gastric lesions in mice.		Others
TN4629	Nemoralisin C		Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.		Others
TN3605	Casegravol		Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.		Others
TN3447	Arjunglucoside I
	Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line wi...
TN1988	Nephthenol		Others
	Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.		Others
TN2913	3-Acetoxy-11-ursen-28,13-olide		Phosphatase
	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A278...		Phosphatase
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ...
TN3429	Aphagranin A		Others
	Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.		Others
TN3660	Cinnamyl caffeate		Calcium Channel
	Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell apoptosis; it possesses potent antiprolif...		Calcium Channel
TN6204	Santin	5,7-Dihydroxy-3,6,4'-trimethoxyflavone	Influenza Virus
	Santin (5,7-Dihydroxy-3,6,4'-trimethoxyflavone) is a flavonoid extracted from birch buds exerting antiproliferative, anti-influenza activity and anti-cancer activity. Santin can be used in studies about anti-IAV drugs.		Influenza Virus
TN4303	Isokaempferide		ATPase , Potassium Channel , Calcium Channel , TNF , Prostaglandin Receptor
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, m...
T72964	Dictyostatin	Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin
	Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule-stabilizing and anti-cancer agent that exhibits antiproliferative activity and has potential for tauopathy research.
TN2936	3-Hydroxy-11-ursen-28,13-olide		Others
	3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-mod...		Others
TN4142	Glochidonol		Others
	Glochidonol exhibits strong inhibitory effects against three human tumor cell lines, MCF-7, NCI-H-460 and SF-268, the GI(50) values of 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, respectively; it also exerts its antiprolif...		Others
TN4623	Nagilactone C		Antifection
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C...		Antifection
T36430	Pheophorbide a
	Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 μg/m...
T75609	7-epi-Isogarcinol
	7-epi-Isogarcinol, a polycyclic polyprenylated acylphloroglucinol (PPAP), exhibits moderate antiproliferative activity by blocking the STAT3 signaling pathway, thereby inducing apoptosis and inhibiting cell migration [1]...
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antip...
TN2328	Zeylenone		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
	Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin...		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
T82692	Comosone II
	Comosone II (Compound 4), a compound isolated from Curcuma zedoaria, exhibits moderate antiproliferative activity. For Ca Ski cancer cells, its IC50 value is 76 μg/mL, showing its inhibitory effect on cancer cell growth.
TN4140	Glochidiol		Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong in...		Others
TN3348	(+)-Acuminatin	Acuminatin	PAFR
	(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90...		PAFR
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
T72742	(-)-Pinocembrin
	(-)-Pinocembrin demonstrates anti-mycobacterial activity against Mycobacterium tuberculosis H37Ra, presenting IC 50 values of 1.11 mg/mL in the dormant phase and 1.21 mg/mL in the active phase. Additionally, this compoun...
T72803	Norartocarpetin
	Norartocarpetin is a potent tyrosinase inhibitor exhibiting significant antibrowning properties useful for food system research, with an IC50 of 0.47 μM. Furthermore, it demonstrates substantial anticancer activity speci...
T37911	Cis-Resveratrol	(Z)-Resveratrol
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, ...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce...

天然物製品

Synonym: BA-90912,NSC 65346

Target: Nucleoside Antimetabolite/Analog, PKC

Mitraphylline

TN1933

Synonym:

Target: IL Receptor, TNF, NF-κB

Gardenin B

TN1675

Synonym:

Target: Apoptosis, ROS, Caspase, NO Synthase

Geniposide

T2212

Synonym:

Target: Beta Amyloid, Influenza Virus

Ginsenoside F2

T3916

Synonym:

Target: Apoptosis, Endogenous Metabolite, Autophagy

2'-acetylacteoside

T6102

Synonym:

Target: Antioxidant, Reductase

(S)-Indoximod

T3S1967

Synonym: N-ME-Tryptophan,Abrine,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Apicidin

T14305

Synonym: OSI 2040

Target: Apoptosis, HDAC, Autophagy

gamma-Mangostin

T4S1637

Synonym: Normangostin

Target: Others, 5-HT Receptor

3-Acetoxy-11-ursen-28,13-olide

Target: Calcium Channel

Santin

TN6204

Synonym: 5,7-Dihydroxy-3,6,4'-trimethoxyflavone

Target: Influenza Virus

Isokaempferide

TN4303

Synonym:

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

Dictyostatin

T72964

Synonym: Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin

Target:

3-Hydroxy-11-ursen-28,13-olide

Target: Apoptosis, ERK, MAPK, Akt, PI3K, mTOR

Synonym: (Z)-Resveratrol

Target:

3-Hydroxyterphenyllin

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03142	IL-27 Protein, Human, Recombinant (His)	Human	CHO
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03072	IFN-omega Protein, Human, Recombinant (His)	Human	HEK293
	IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide s...
TMPY-06983	IFN gamma Protein, Human, Recombinant (E. coli)	Human	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-03356	IFN gamma Protein, Mouse, Recombinant	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-01714	IFN gamma Protein, Human, Recombinant	Human	CHO
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02827	IFN gamma Protein, Rat, Recombinant (hFc)	Rat	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-03467	IFN-beta Protein, Mouse, Recombinant	Mouse	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-00831	IFN-beta Protein, Human, Recombinant (hFc)	Human	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-03145	IFN-beta Protein, Human, Recombinant	Human	CHO
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPH-02451	IFN gamma Protein, Marmota monax, Recombinant (His)	Marmota monax	Yeast
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproli...
TMPH-00373	IFN gamma Protein, Chicken, Recombinant (GST)	Chicken	E. coli
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproli...
TMPJ-01371	Limitin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN-α, IFN-β, and IFN-ω and binds to the IFN-α/β receptors. Like IFN-α and IFN-β, limitin...
TMPH-00278	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPH-00279	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPY-00833	IFN-omega Protein, Human, Recombinant (hFc)	Human	HEK293
	IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide s...
TMPH-01555	IFITM1 Protein, Human, Recombinant (GST)	Human	E. coli
	IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against ...
TMPY-03664	IFN gamma Protein, Ferret, Recombinant (His)	Ferret	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-04191	IFN gamma Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-00527	IFN gamma Protein, Rhesus, Recombinant	Rhesus	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02323	IFN gamma Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02322	IFN gamma Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-03828	IFN-beta Protein, Rhesus, Recombinant (mFc)	Rhesus	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-02456	IFN-beta Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...